Enclomiphene Overview
Enclomiphene is the purified E-isomer of Clomiphene Citrate, a selective estrogen receptor modulator (SERM). It reactivates the hypothalamic-pituitary-testicular axis (HPTA) by blocking estrogenic feedback at the hypothalamus, leading to increased endogenous testosterone. Compared to standard mixed-isomer clomiphene, Enclomiphene provides a cleaner, shorter-acting, fertility-friendly hormonal response, supporting performance, recovery, and wellness.
Compound Profile
- Name: Enclomiphene (Enclomiphene Citrate)
- CAS Number: 7599-79-3 (citrate salt)
- Molecular Formula: C32H36ClNO8 (citrate salt)
- Main Function: Restores endogenous testosterone by increasing LH and FSH via hypothalamic ER antagonism
- Mechanism: Blocks estrogen receptors in the hypothalamus → removes negative feedback → pituitary releases LH & FSH → testes increase natural testosterone while preserving spermatogenesis
Key Benefits
- Reactivates HPTA and increases endogenous testosterone
- Maintains fertility and sperm counts compared to exogenous testosterone
- Provides a cleaner hormonal profile than mixed-isomer Clomiphene
- Supports mood, motivation, libido, and recovery
- Helps rebalance estrogen-dominant states
- Non-steroidal, fertility-friendly hormonal support
Research & Applications
- BJU International (2016): Oral Enclomiphene increased testosterone while maintaining sperm counts vs. testosterone gel, which reduced spermatogenesis
- Promoted as “restoration instead of replacement” in HPTA reactivation and secondary hypogonadism models
- Applications include hormonal balance restoration, performance support, recovery enhancement, and fertility preservation
- Supports energy, body composition, and training drive indirectly via restored testosterone
Possible Side Effects
- Generally well-tolerated
- Mild, temporary mood fluctuations or irritability
- Occasional headache or pressure sensation
- Temporary libido changes
Note: Informational content only.